Chemix Pre Workout

Some of the superior ingredients might not be well known by most, so here is a slight breakdown on some of the key ingredients in this extremely powerful formula:

PeakO2™: This patented blend of 6 mushrooms has been shown to increase time-to-exhaustion by 60-fold, increase power output by 17.6% and peak power by 2.8% vs a placebo. This ingredient has been shown to increase ATP production (more energy), VO2 Max (better Oxygen Flow) and antioxidants, all of which will allow you to perform better in the gym. 1 Scoop of Chemix Pre Workout contains 2g.

Kanna (Sceletium tortuosum): This ingredient is a unique ingredient that will give you an added effect you won't get from other pre workouts. This is an all natural herb that acts as a nootropic (brain vitamin) and interacts with 77 different receptors in your brain. It has been shown to be a natural SSRi (selective serotonin reuptake inhibitor), which increases serotonin levels and blocks is uptake. This boosts mood, giving you an extremely focused and euphoric feeling. Think extreme happy thoughts. Kanna also acts as a monoamine releasing agent, meaning it increases dopamine & adrenaline levels (again, happy feeling and extreme energy rush). Kanna has also been proven to inhibit phosphodiesterase 4 (PDE4), which allows for better mood, increased long-term memory formation and wakefulness. The studied dose of this ingredient is 25mg, but Chemix boasts a 1000mg dose at 2:1 ratio to give you optimal results.

GlycerPump™: GlycerPump is the new version of a powdered glycerol supplement that is standardized for 65% glycerol. Glycerol is an ingredient that attracts lots of water and helps hydrate cells very effectively. This is known as a state of hyperhydration, which can increase performance and give you pumps that you have never before seen! You get 3g of this ingredient in Chemix Pre.

Lions Mane(Organic) standardized for 25% beta glucans: Lions Mane is a nootropic (brain vitamin) and cognitive-enhancing mushroom. It has been studied and shown to increase nerve growth factor while simultaneously decreasing beta amyloid levels (which at high levels cause mental decline). This decreases overall inflammation in the rain and can improve levels of cognition, memory and mental fatigue. Lions Mane also has been shown to increase dopamine production and enhance euphoria. Lions Mane is dosed at 600mg/scoop.

Exothermic Energy Amalgam: This is a very specific combination of extremely strong stimulants, nootropics (brain vitamins) and adaptogens that allow for an increase in energy, focus, euphoria and decrease mental fatigue. The Guerrilla Chemist spent years devoloping this exact blend of the cognitive and performance-enhancing ingredients, and each of the ingredients is there at an exact dose for maximum synergy and effect. For this reason, he has decided to protect his formula and make it a proprietary blend. After almost a full year of research and development, he didn't want anyone to copy the exact formula.

Chemix King of Pumps

King of Pumps is one of the ultimate non-stimulant, nitric oxide boosting pre workout formulas on the market. It is jam packed with 7 different ingredients, all of which are studied and shown to increase N.O. production using different mechanisms. Every ingredient is used in clinical doses to maximize performance.

King of Pumps is a non-stim (no caffeine/energy rush/crash) formula and approach designed to maximize vasodilation, Nitric Oxide production, cellular swelling, hyperhydration & glycogen-induced pumps during your workout. There are multiple pathways that KIng of Pumps allows your muscles to be engroged with blood and water for some of the most intense pumps that you could possibly achieve.

Chemix EAA

Chemix Essential Amino Acids are the ultra-premium amino acid formula designed to enhance endurance, improve recovery, reduce overall muscle soreness and hydrate your muscle bellies like never before!

The Advanced formula combines ingredients that have been researched at clinical doses, giving you a potent EAA to ensure a perfect workout and aid in recovery to make sure progress will be attained.

Amino acids are known to be the key nutrient in muscle protein synthesis and a key factor in overall muscle growth. There are 20 amino acids that are genetically coded for, and 9 of these are considered essential amino acids, because your body does not synthesize them on its own. These need to come from exogenous sources, like food and supplements. Of the 9, the most familiar to most people are the BCAAs (leucine, isoleucine & valine). It has been shown that leucine is the pre-cursor to muscle protein synthesis, so essential leucine levels are needed to build muscle.

Furthermore, several studies have shown that EAA consumption post workout enhances protein synthesis, even without carbs.

Chemis EAA uses a specific ratio of EAAs based on research showing optimal EAA levels that increase muscle protein synthesis post workout. 

You can guarantee that Chemix EAA has a clinical dose of all 9 EAAs and was formulated to maximize muscle protein synthesis by supplying your muscles with the necessary amino acids to help build the new muscle tissue!

The Guerrilla Chemist Has Spent Countless Hours Formulating The PERFECT Blend Of Ingredients To Help Increase Natural Testosterone Production As Well As Regulate Estrogen To Optimize Your Hormones So You Can Make Progress At A Pace You Have Never Experienced. Our Super Potent Anabolic Matrix Is The Answer To Improving Strength, Explosive Power, Enhanced Energy, Amazing Endurance, And A Great Way To Keep Estrogen Regulated To Mitigate Negative Side Effects And Regulate Unwanted Water Retention.

Our New Anabolic Formulation Natabolic Contains Natural Phytoandrogens To Help Build Muscle Faster And Easier Than Ever Before. Natabolic Contains Premium Ingredients Like Byroviron, KSM-66, Laxogenin, Boron, And Arimistane That Not Only Aid In Boosting Testosterone But Also Help Regulate Estrogen To Give You A Harder And Drier Look Overall.

HOW DOES CHEMIX NATABOLIC WORK?

NATABOLIC is THE strongest natural anabolic and testosterone-boosting product on the market. Period. Loaded with 9 extremely potent and unique ingredients, NATABOLIC is designed to help elevate you to an extreme anabolic state to build muscle, burn fat and control estrogen.

TESTOSTERONE BOOSTING INGREDIENTS:

ByroViron: the trademarked version of Bryonia lacinosa extract is an extremely potent, all-natural herb that has been used for centuries in Ayurvedic medicine for its ability to dramatically increase testosterone and fertility. Bryonia works by increasing BOTH luteinizinghormone(LH) and follicle-stimulating hormone(FSH), key hormones which release testosterone from your Leydig cells in your testes and increase sperm production and motility. Bryonia also increases sex drive and the size/weight of your testes(no shrunken balls!). By increasing testosterone levels, this can directly translate to gaining lean muscle mass, getting stronger in the gym, as well as possibly losing body fat. One study even showed that testosterone leves were 6.5X greater than the placebo! NATABOLIC contains a whopping 1000mg of Byroviron per serving.

Nigella Sativa Seeds: Nigella sativa has also been used Ayurvedic medicine for a very long time for its anti-diabetic, antioxidant and fertility properties. Nigella sativa has been shown to elevate luteinizing hormone(LH) levels, possibly from protecting your testes from lipid peroxidation damage. Lipid peroxidation is cell damage caused by free radicals and/or reactive- oxygen species(ROS). Nigella is loaded with bioactive compounds like alkaloids, tannins, saponins and more. The main antioxidants found in nigella sativa seeds are thymoquinone and multiple unsaturated fats. These compounds can bind to free radicals and neutralize them. Some studies show an increase in LH by 17%, which in turn, increases testosterone production! 6 Nigella also has a unique property where it protects your free testosterone levels from dropping. There are also a myriad of studies showing the positive effect of Nigella on fertility, sperm production, and motility.

KSM-66 Ashwagandha (5% withanolides): KSM-66 is the trademarked version of the adaptogenic compound ashwagandha. Ashwagandha is an Ayurvedic herb that has been used for over 3,000 years to help with things like stress, fatigue, sexual health, inflammation and fertility. The bioactives in ashwagandha are known as withanolides. KSM-66 is the only ashwagandha on the market that uses the exact ratios of withanolides naturally found in the root.

In a 2015 study using 300mg of KSM-66 twice daily for 8 weeks, males aged 18-50 gained 75% more strength for upper body and 50% for lower body, as well as decreases in body fat. This study seems to support the claim from the 2012 study using 300mg twice daily where subjects increased LH levels by 34%, which corresponded to a 17% increase in testosterone levels! Another great benefit from KSM-66 is its remarkable ability to reduce cortisol. This helps not only with mental stress, but can help burn stubborn body fat.

Boron (as Boron Citrate): Boron is a micronutrient that plays an important role in many
metabolic processes, one of them being beneficial to the body’s use of sex hormones. Studies have shown that boron supplementation(6mg) can increase testosterone levels in both men and women. More importantly, boron has been shown to increase FREE testosterone. Free testosterone is testosterone not bound to sex hormone binding globulin, and that your body can use. Almost 98% of all testosterone is bound, so any increase in free testosterone can have a dramatic effect on building muscle. Boron was shown to increase free testosterone by 22%. One suggested mechanism is that boron supplies a pathway for testosterone to not convert to
estradiol.

NATURAL ANABOLIC INGREDIENTS:

Korean Mistletoe Extract: Korean Mistletoe extract has been used in traditional Eastern
medicine for thousands of years as an anti-diabetic/anti-obesity treatment. However, recent data shows that it can actually upregulate genes specific to muscle hypertrophy(mTOR, Pi3K/Atk). That’s right! It can increase expression of genes that turn on muscle building! Not only that, but Korean mistletoe reduced the expression of Atrogin-1, a gene associated with muscle atrophy! This wonder herb can help you add lean muscle mass and prevent muscle shrinking. Studies also show it can increase exercise endurance and time-to-exhaustion by approximately 180%!

Eucommia ulmoides bark: Eucommia ulmoides is a plant that contains isoflavinoids called phytoandrogens. These molecules essentially act like testosterone in the following ways: they bind to the androgen receptor and turn on the same genes to produce muscle growth. Phytoandrogens are not actually a human sex hormone, but made up of the same building blocks (triterpenes) and interact with the androgen receptor in a very similar fashion as androgens(testosterone). Supplementing with Eucommia has shown an increase of androgen receptor expression of up to 204%! It was also shown that Eucommia contains a “lipidic augmenter, “ which basically means there are other fatty acid molecules in Eucommia that assist in the actual binding of androgens(testosterone, DHT) and the phytoandrogens to the androgen receptor. This means there is actual SYNERGY between androgens, Eucommia(phytoandrogens) and the androgen receptor!

Eriobotrya Japonica(Loquat) Extract: Eriobotrya japonica is a natural anabolic/anti-catabolic botanical that works by manipulating genes responsible for building and wasting muscle. One of the main bioactives ursolic acid. Recently, its been shown that supplementing with loquat can increase muscle protein synthesis via activation of mTOR. It has akso been shown to regulate muscle atrophy(shrinking) by regulating insulin/IGF-1 levels. Even more recent research points to loquat downregulating genes associated with muscle breakdown! This allows you to stay in a constant state of muscle anabolism!

5-alpha-hydroxy-Laxogenin: 5-alpha-hydorxy-laxogenin is a plant sterol that seems to have anabolic effects in humans. It has been shown to increase strength in athletes taking 22mg of the 5-alpha-hydroxy isomer for 4 weeks. Muscle size also increased in participants taking the supplement. Data is limited, but plant sterols like this one have been shown to have anabolic properties and increase muscle protein synthesis. This product contains 100mg of 5-alpha-hydroxy-laxogenin!

3,5-androstadien-7,17,dione: I wish this had a shorter name, but this 7-keto metabolite of DHEA compound is a natural aromatase inhibitor. That means it can help lower the conversion of testosterone to estrogen via blocking the enzyme aromatase. You need some estrogen for normal function, so this supplement will not cause your estrogen to plummet. However, it may prevent some of the unwanted side effects of higher testosterone levels like water retention and possibly gynecomastia.

References:

1. Chauhan, N. S., and V. K. Dixit. "Effects of Bryonia laciniosa seeds on sexual behaviour of male
rats." International Journal of Impotence Research 22.3 (2010): 190-195.
2. Sud, Khyati, and Sushant Sud. "A Scientific Review on Shivlingi Beej (Bryonia Laciniosa): A
Mystical Ethno-Medicine for Infertility." European Journal of Biomedical 4.8 (2017): 1098-1102.
3. Chauhan, N. S., D. K. Saraf, and V. K. Dixit. "Effect of vajikaran rasayana herbs on
pituitary–gonadal axis." European Journal of Integrative Medicine 2.2 (2010): 89-91.
4. Rasagnayadavalli Venugopal, Y., and S. A. Sreenivas. "Phytochemistry and Pharmacology of
Bryonia laciniosa: A Review." Int J Pharm 32.04 (2012): 542e-7.
5. Parandin, Rahmatollah, Namdar Yousofvand, and Rostam Ghorbani. "The enhancing effects of
alcoholic extract of Nigella sativa seed on fertility potential, plasma gonadotropins and
testosterone in male rats." Iranian journal of reproductive medicine 10.4 (2012): 355.
6. Datau, E. A., et al. "Efficacy of Nigella sativa on serum free testosterone and metabolic
disturbances in central obese male." Acta Medica Indonesiana 42.3 (2010): 130-134.
7. Haseena, S., et al. "Effect of nigella sativa seed powder on testosterone and LH levels in
sterptozotocine induced diabetes male albino rats." Journal of pharmaceutical sciences and
research 7.4 (2015): 234.
8. Mahdavi, Reza, Javad Heshmati, and Nazli Namazi. "Effects of black seeds (Nigella sativa) on
male infertility: A systematic review." Journal of Herbal Medicine 5.3 (2015): 133-139.
9. Ambiye, Vijay R., et al. "Clinical evaluation of the spermatogenic activity of the root extract of
Ashwagandha (Withania somnifera) in oligospermic males: a pilot study." Evidence-Based
Complementary and Alternative Medicine 2013 (2013).
10. Lopresti, Adrian L., et al. "An investigation into the stress-relieving and pharmacological actions of
an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled
study." Medicine 98.37 (2019).
11. Ferrando, Arny A., and Nancy R. Green. "The effect of boron supplementation on lean body
mass, plasma testosterone levels, and strength in male bodybuilders." International Journal of
Sport Nutrition and Exercise Metabolism 3.2 (1993): 140-149.
12. Pizzorno, Lara. "Nothing boring about boron." Integrative Medicine: A Clinician's Journal 14.4
(2015): 35.
13. Jeong, Juseong, et al. "Korean mistletoe (Viscum album coloratum) extract regulates gene
expression related to muscle atrophy and muscle hypertrophy." BMC complementary and
alternative medicine 17.1 (2017): 1-10.
14. Jeong, Juseong, et al. "Activation of Signaling Pathways for Protein Synthesis by Korean
Mistletoe (Viscum album coloratum) Extract in a Mouse Model of Muscle Atrophy." The Korean
Journal of Food And Nutrition 30.2 (2017): 371-377.
15. Ong, Victor YC, and Benny KH Tan. "Novel phytoandrogens and lipidic augmenters from
Eucommia ulmoides." BMC Complementary and Alternative Medicine 7.1 (2007): 3.
16. Sung, Bokyung, et al. "Loquat leaf extract enhances myogenic differentiation, improves muscle
function and attenuates muscle loss in aged rats." International journal of molecular
medicine 36.3 (2015): 792-800.
17. Noh, Kyung Kyun, et al. "Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced
muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats." Molecular
medicine reports 12.3 (2015): 3607-3614.
18. Numazawa, Mitsuteru, et al. "Synthesis of androst-5-en-7-ones and androsta-3, 5-dien-7-ones
and their related 7-deoxy analogs as conformational and catalytic probes for the active site of
aromatase; Journal of medicinal chemistry 37.14 (1994): 2198-2205.

Assist Your Recovery And Induce Restfulness With The All New Chemix Ultra Premium Sleep Aid. The Guerrilla Chemist Has Gone Back To The Lab And Formulated Our First Ever Ultra Premium Sleep Aid Product. This One Of A Kind Formulation Will Turn Your Lights Out When It's Time To Get Your Rest. Chemix Sleep Will Provide The Best In Rest And Recovery With No Excess Hangover Leaving You Ready To Take On The Day With Plenty Of Energy And Focus.

SLEEP is an all-natural, multifaceted sleep product designed to promote sleepiness and restful sleep to ensure maximum recovery. Quality sleep is one of the most important and essential actions your body needs to function properly. It is estimated that up to 33% of all adults do not get enough quality sleep. SLEEP is specifically designed to help fight off restlessness via different mechanisms of action, including inducing sleep and staying asleep.

HOW DOES CHEMIX SLEEP WORK?

GABAiclinÔ is a trademarked extract of Scutellaria baicalensis, standardized for 30% of the main active baicalin. Baicalin is a positive allosteric agonist for your GABA_A receptors. g-aminobutyric acid, aka GABA is your main inhibitory neurotransmitter that essentially tells your brain it’s time to get ready for sleep. Once baicalin binds to your GABA_A receptor, it activates the receptor and elicits sedative, hypnotic, muscle relaxant and anxiolytic(anti-anxiety) properties.  This is the same mechanism and receptor that a class of sleep medications known as benzodiazepines interacts with. Baicalin has been shown to increase slow-wave sleep(deep sleep), as well as REM(rapid eye movement) sleep. REM sleep is extremely valuable to your body, as it releases growth hormone(GH) to help aid in recovery.

MagnaSleepÔ is an extremely potent form of magnolia bark extract(MBE), standardized for 90% of two powerful active phenolic compounds: magnolol and honokiol.  These two bioactives also act on your GABA_A receptors to help reduce anxiety and prepare your body for sleep. MBE has been used for thousands of years in Chinese and Japanese tradition medicine for help promote sleep and reduce anxiety. Magnolol and Honokiol both have very high binding affinity to your GABA_A receptors, specifically interacting with the benzodiazepine binding site. This binding potentiates the sleep inducing-effect of baicalin. Since magnolol and honokiol can quickly be metabolized via glucuronidation, a hefty 25mg dose of BioPerineÒ(black pepper extract) was added to inhibit this process.

Cussonia zimmermannii is an African herb that has been studied for bioactive constituents that modulate your GABA receptors to induce sleep. The rootbark extract of C. zimmermannii has some very unique compounds known as polyacetylenes that have an extremely high affinity to GABA_A receptors. However instead of binding directly to the receptor binding pocket, they bind to a slightly different area on the GABA_A receptors and enhance the effects of compounds like magnolol and honokiol that bind directly to the binding pocket. This is known as positive allosteric modulation and is a very synergistic property.   These compounds have been shown to promote restfulness sleep, as well as staying asleep longer.

Hesperidin is one of the main bioactive compounds from citrus peel extract. It is a polyphenolic compound that has been shown to induce sleep, but does not act on the GABA receptor or benzodiazepine binding site.  Studies show hesperidin interacts with your extracellular signal-regulated kinases 1/2(ERK1/2), located in the cortex and cerebellum. Hesperidin inhibits the activity of ERK1/2, which may be linked to sedation. Studies show that hesperidin can induce sleepiness and enhance sleep, and may potentiate other sleep-promoting compounds that activate your GABA_A receptors.

Apigenin is a polyphenolic flavonoid that is one of the most abundant and well-studied. Apigenin’s mechanism of action is not directly on the GABA-benzodiazepine receptor, but does modulate its’ activity. Studies show it has a synergistic effect when combined with GABA_A agonists, like baicalin, magnolol and honokiol.  It has been shown to reduce locomotor activity, which prevents restlessness and may help induce sleep. One study showed subjects taking apigenin slept for longer durations vs the placebo. Apigenin is also subject to glucuronidation, so absorption is critical.  With 25mg of BioPerineÒ added to prevent this metabolism, you can be sure that the large dose of apigenin will be absorbed and utilized.

I formulated SLEEP because I have had sleeping issues all of my adult life. I have tried countless over-the-counter sleeping aids, melatonin, as well as 11 different pharmaceuticals.  This combination of ingredients at clinical doses has dramatically improved my ability to fall asleep, my biggest issue, as well as stay asleep, my 2^nd biggest issue.  I scoured papers to look for natural sleep-enhancing compounds and I truly believe this formula will help anyone looking to get more restful sleep to help fully recover not only from exercise but from mental stress, as well.

-GC

References:

1. Chang HH, Yi PL, Cheng CH, et al. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 2011;135(2):359-368.
2. Shi, Yuan, et al. "Herbal insomnia medications that target GABAergic systems: a review of the psychopharmacological evidence." Current Neuropharmacology3 (2014): 289-302.
3. Ai, Jinglu, Xiaomei Wang, and Mogens Nielsen. "Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro." Pharmacology1 (2001): 34-41.
4. Squires, Richard F., et al. "Honokiol and magnolol increase the number of [3 H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites." Neurochemical research12 (1999): 1593-1602.
5. Chen, Chang-Rui, et al. "Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABAA receptor in mice." Neuropharmacology6 (2012): 1191-1199.
6. Senn, Martin W. Structures and evaluation of biologically active constituents of" Cussonia Zimmermannii" harms. Diss. University_of_Basel, 2006.
7. Martínez, M. Cecilia, et al. "Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice." Pharmacology Biochemistry and Behavior2 (2009): 291-296.
8. Fernández, Sebastián P., et al. "Synergistic interaction between hesperidin, a natural flavonoid, and diazepam." European journal of pharmacology2-3 (2005): 189-198.
9. Fernández, Sebastián, et al. "Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis." Pharmacology Biochemistry and Behavior2 (2004): 399-404.
10. Salehi, Bahare, et al. "The therapeutic potential of apigenin." International journal of molecular sciences6 (2019): 1305.
11. Kim, Jae-Wook, et al. "Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation." Archives of pharmacal research2 (2012): 367-373.

Gazola, Andressa C., et al. "Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp." Revista Brasileira de Farmacognosia 25.2 (2015): 158-163.

Chemix CEO The Guerrilla Chemist is back with his long awaited Nootropic Formulation that not only decreases mental fatigue but increases cognition to enhance productivity and provide focus at levels you have never seen before.

Redefine your focus with our brand new caffeine free nootropic blend helping you to harness the power of incredible ingredients like Lions Mane Extract, Huperzine A, Ivy Leaf Extract, Kanna, and more which deliver mental acuity beyond your wildest imagination.

HOW DOES CORTIBLOC WORK?

 CortiBloc™ is a one-of-a-kind natural cortisol inhibitor that can help with weight loss and regulate cortisol and blood glucose metabolism. The main ingredient in CortiBloc™ is emodin, an anthraquinone compound isolated mainly from the root and rhizome of polygonum cuspitatum, which acts as an 11βhydroxysteroid dehydrogenase 1(11β-HSD1) inhibitor. This enzyme, located in your liver and fat cells is responsible for the conversion of cortisone(the inactive glucocorticoid) into cortisol(the active form).

Glucocorticoids like cortisol can have deleterious effects on your body if levels get too high. Research has shown that elevated levels of glucocorticoids like cortisol can inhibit glucose uptake in skeletal muscle and can lead to fat gain, obesity, insulin resistance, hypertension, dyslipidemia and type-2 diabetes. Cortisol, which is produced in your adrenal glands in response to stress is good in small quantities and at the right time. However, long term elevated levels can have serious health implications, as mentioned earlier. Emodin can stop elevated cortisol levels right at the source. Emodin is a selective inhibitor of 11β-HSD1 only, not 11β-HSD2 which is found in your kidneys. Inhibiting this enzyme can cause major health effects such as sodium/potassium absorption/elimination, buildup of excess mineralocorticoids, interfere with aldosterone and affect kidney function.

Emodin inhibits 11β-HSD1 by blocking the enzyme site from sending a hydride from NADP to cortisone to produce cortisol. Studies show emodin inhibits the enzyme by up to 46% in adipose tissue(fat cells) which means your body is producing almost half of the cortisol it normally would. This can lead to fat loss, reduction in stress, decreased insulin resistance and increased insulin sensitivity. Emodin also reduced fasting blood glucose levels by 77% after taken orally for 7 days, as well as overall plasma insulin levels by 66% relative to the control. In another study, emodin was shown to reduce appetite and bodyweight in mice(13.9% reduction in bodyweight).

As you can see, emodin is a very powerful ingredient for inhibiting cortisol and insulin-induced weight gain. Unfortunately, the oral bioavailability is very low. In order to fix this issue, we added a large dose of piperine, commonly known as black pepper extract. In a study combining emodin with piperine showed a marked increase in bioavailability via inhibiting glucuronidation. This is the process where a glucose molecule is attached to emodin to make it more water soluble and easy to expel from the body. By stopping this process, the piperine allows emodin to maximally be absorbed and inhibit the formation of cortisol and help you meet and exceed your weight loss goals. This product can be taken by both men and women and works especially well for high-intensity athletes and fitness competitors.

______________________________________________________

Feng, Ying, et al. "Emodin, a natural product, selectively inhibits 11β‐hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet‐induced obese mice." British journal of pharmacology 161.1 (2010): 113- 126. Di, Xin, Xin Wang, and Youping Liu. "Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats." Journal of pharmaceutical and biomedical analysis 115 (2015): 144-149. Wang, Yue-jing, et al. "Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice." Acta Pharmacologica Sinica 33.9 (2012): 1195.

Read The Studies On The Ingredients Below

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2010.00826.x
https://www.nature.com/articles/aps201287#introduction